Development and validation of the Gender-Equity Model for Liver Allocation (GEMA) to prioritise candidates for liver transplantation: a cohort study. ↗️
Rodríguez-Perálvarez ML, Gómez-Orellana AM, Majumdar A, et al.
Pivotal GEMA study. The model was trained and validated internally in a UK cohort of 7,860 patients, and externally validated in Australia (1,638 patients). GEMA was shown to more accurately predict the risk of waiting list mortality compared to the MELD family of models. It was also able to eliminate existing gender disparities and prevent a significant number of waitlist deaths. These results made GEMA the first externally validated model capable of eliminating gender disparities in access to liver transplantation.
Development and validation of a mathematical equation to estimate glomerular filtration rate in cirrhosis: The royal free hospital cirrhosis glomerular filtration rate. Hepatology 2017;65:582-591. ↗️
Kalafateli M, Wickham F, Burniston M, Cholongitas E, Theocharidou E, Garcovich M, et al
Study in which the Royal Free glomerular filtration rate formula for cirrhosis was developed and validated. This formula was specifically designed to measure kidney function in patients with chronic liver disease, including decompensated cirrhosis.
Superiority of the new sex-adjusted models to remove the female disadvantage restoring equity in liver transplant allocation. Liver Int 2024;44:103-112. ↗️
Marrone G, Giannelli V, Agnes S, Avolio AW, Baiocchi L, Berardi G, et al.
A study carried out in Italy, in the Lazio region, compared new prioritisation models designed to eliminate gender disparities and found GEMA to be superior to the other models in terms of predicting waiting list mortality.
